APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

B. Kopp, Jeffrey; W. Nelson, George; Sampath, Karmini; C. Johnson, Randall; Genovese, Giulio; An, Ping; J. Friedman, David; Briggs, W; A. Dart, Richard; M. Korbet, Stephen; H. Mokrzycki, Michele; L. Kimmel, Paul; Limou, Sophie; S. Ahuja, Tejinder; S. Berns, Jeffrey; Fryc, Justyna; E. Simon, Eric; C. Smith, Michael; Trachtman, Howard; M. Michel, Donna; R. Schelling, Jeffrey; Vlahov, David; R. Pollak, Martin; A. Winkler, Cheryl

doi:10.1681/asn.2011040388

Public

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

Published in Journal of the American Society of Nephrology • Oct 14, 2011

Authors:

Jeffrey B. Kopp

George W. Nelson

Karmini Sampath

Abstract

Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271 African American cases, 168 European American ...

Subject

Focal segmental glomerulosclerosis

Odds ratio

Nephropathy

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