Ion‐pairing reversed‐phase liquid chromatography/electrospray ionization mass spectrometric analysis of 76 underivatized amino acids of biological interest: a new tool for the diagnosis of inherited disorders of amino acid metabolism

Piraud, Monique; Vianey‐Saban, Christine; Pétritis, Konstantinos; Elfakir, Claire; Steghens, Jean‐Paul; Bouchu, Denis

doi:10.1002/rcm.1957

Public

Ion‐pairing reversed‐phase liquid chromatography/electrospray ionization mass spectrometric analysis of 76 underivatized amino acids of biological interest: a new tool for the diagnosis of inherited disorders of amino acid metabolism

Published in Rapid Communications in Mass Spectrometry • May 24, 2005

Authors:

Monique Piraud

Christine Vianey‐Saban

Konstantinos Pétritis

Abstract

Seventy-six molecules of biological interest for the diagnosis of inherited disorders of amino acids (AA) metabolism have previously been demonstrated to be detectable in electrospray ionization tandem mass spectrometry (ESI-MS/MS) positive mode without derivatization. Reversed-phase liquid chromato...

Subject

Chemistry

Chromatography

Derivatization

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