<i>LMO2</i>
                    -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S.; Von Kalle, C.; Schmidt, M.; P. McCormack, M.; Wulffraat, N.; Leboulch, P.; Lim, A.; S. Osborne, C.; Pawliuk, R.; Morillon, E.; Sorensen, R.; Forster, A.; Fraser, P.; I. Cohen, J.; de Saint Basile, G.; Alexander, I.; Wintergerst, U.; Frebourg, T.; Aurias, A.; Stoppa-Lyonnet, D.; Romana, S.; Radford-Weiss, I.; Gross, F.; Valensi, F.; Delabesse, E.; Macintyre, E.; Sigaux, F.; Soulier, J.; E. Leiva, L.; Wissler, M.; Prinz, C.; H. Rabbitts, T.; Le Deist, F.; Fischer, A.; Cavazzana-Calvo, M.

doi:10.1126/science.1088547

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LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Shared by NobleBlocks on Oct 17, 2003 • 12:00 AM UTC

Authors:

S. Hacein-Bey-Abina

C. Von Kalle

M. Schmidt

Abstract

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as Î³ chain (Î³c) deficiency] in 9 out of 10 patients by retrovirus-mediated Î³c gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncontrolled expone...

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