<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S.; von Kalle, Christof; Schmidt, Manfred; P. McCormack, Matthew; M. Wulffraat, N.; Leboulch, Philippe; Lim, Apiradee; S. Osborne, Cameron; Pawliuk, Robert; Morillon, Estelle; U. Sorensen, Ricardo; Förster, A.; Fraser, Peter; I. Cohen, J.; de Saint Basile, Geneviève; E. Alexander, Ian; Wintergerst, Uwe; Frébourg, Thierry; Aurias, Alain; Stoppa‐Lyonnet, Dominique; Romana, Serge; Radford-Weiss, I; Gross, Fabian; Valensi, F; Delabesse, Éric; Macintyre, Elizabeth; Sigaux, F; Soulier, Jean; E. Leiva, Lily; Wissler, Manuela; Prinz, Claudia; H. Rabbitts, Terence; Le Deist, Françoise; Fischer, Alain; Cavazzana, Marina

doi:10.1126/science.1088547

Public

LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Published in Science • Oct 16, 2003

Authors:

S. Hacein-Bey-Abina

Christof von Kalle

Manfred Schmidt

Abstract

We have previously shown correction of X-linked severe combined immunodeficiency [SCID-X1, also known as gamma chain (gamma(c)) deficiency] in 9 out of 10 patients by retrovirus-mediated gamma(c) gene transfer into autologous CD34 bone marrow cells. However, almost 3 years after gene therapy, uncont...

Subject

Genetic enhancement

Gene

Biology

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