WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Zheng, Hou-Feng; H Tobias, Jon; Duncan, Emma; M Evans, David; Eriksson, Joel; Paternoster, Lavinia; M Yerges-Armstrong, Laura; Lehtimäki, Terho; Bergström, Ulrica; Kähönen, Mika; J Leo, Paul; Raitakari, Olli; Laaksonen, Marika; C Nicholson, Geoffrey; Viikari, Jorma; Ladouceur, Martin; Lyytikäinen, Leo-Pekka; Medina-Gomez, Carolina; Rivadeneira, Fernando; L Prince, Richard; Sievanen, Harri; D Leslie, William; Mellström, Dan; A Eisman, John; Movérare-Skrtic, Sofia; Goltzman, David; A Hanley, David; Jones, Graeme; St Pourcain, Beate; Xiao, Yongjun; J Timpson, Nicholas; Davey Smith, George; R Reid, Ian; M Ring, Susan; N Sambrook, Philip; Karlsson, Magnus; M Dennison, Elaine; P Kemp, John; Danoy, Patrick; Sayers, Adrian; G Wilson, Scott; Nethander, Maria; McCloskey, Eugene; Vandenput, Liesbeth; Eastell, Richard; Liu, Jeff; Spector, Tim; D Mitchell, Braxton; A Streeten, Elizabeth; Brommage, Robert

doi:10.1371/journal.pgen.1002745

Public

WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.

Shared by NobleBlocks on Jul 1, 2012 • 12:00 AM UTC

Authors:

Hou-Feng Zheng

Jon H Tobias

Emma Duncan

Abstract

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individua...

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