WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

Zheng, Hou‐Feng; H. Tobias, Jonathan; L. Duncan, Emma; M. Evans, David; Eriksson, Joel; Paternoster, Lavinia; M. Yerges-Armstrong, Laura; Lehtimäki, Terho; Bergström, Ulrica; Kähönen, Mika; Leo, Paul; T. Raitakari, Olli; Laaksonen, Marika; C. Nicholson, Geoffrey; Viikari, Jorma; Ladouceur, Martin; Lyytikäinen, Leo‐Pekka; Medina‐Gómez, Carolina; Rivadeneira, Fernando; L. Prince, Richard; Sievänen, Harri; D. Leslie, William; Mellström, Dan; A. Eisman, John; Movérare‐Skrtic, Sofia; Goltzman, David; A. Hanley, David; Jones, Graeme; St Pourcain, Beaté; Xiao, Yongjun; J. Timpson, Nicholas; Davey Smith, George; R. Reid, Ian; M. Ring, Susan; N. Sambrook, Philip; K. Karlsson, Magnus; Dennison, Elaine; P. Kemp, John; Danoy, Patrick; Sayers, Adrian; G. Wilson, Scott; Nethander, Maria; McCloskey, Eugène; Vandenput, Liesbeth; Eastell, Richard; Liu, Jeff; D. Spector, Tim; D. Mitchell, Braxton; A. Streeten, Elizabeth; Brommage, Robert; Pettersson, U.; A. Brown, Matthew; Ohlsson, Claes; Brent Richards, J.; Lorentzon, Mattias

doi:10.1371/journal.pgen.1002745

Public

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

Published in PLoS Genetics • Jul 5, 2012

Authors:

Hou‐Feng Zheng

Jonathan H. Tobias

Emma L. Duncan

Abstract

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and bone mineral density (BMD) by performing two separate genome-wide association study (GWAS) meta-analyses for CBT in 3 cohorts comprising 5,878 European subjects and for BMD in 5 cohorts comprising 5,672 individua...

Subject

Single-nucleotide polymorphism

Genome-wide association study

SNP

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