DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid.

ME, Major; L, Vitvitski; MA, Mink; M, Schleef; RG, Whalen; C, Trépo; G, Inchauspé

doi:10.1128/jvi.69.9.5798-5805.1995

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DNA-based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid.

Shared by NobleBlocks on Sep 1, 1995 • 12:00 AM UTC

Authors:

Major ME

Vitvitski L

Mink MA

Abstract

Vectors expressing the first 58 amino acids of the hepatitis C virus (HCV) nucleocapsid alone or as a fusion protein with the middle (pre-S2 and S) or major (S) surface antigens of hepatitis B virus (HBV) were constructed. Intramuscular immunization of BALB/c mice with the chimeric constructs in the...

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