Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Lister, Adam; Nedjadi, Taoufik; R. Kitteringham, Neil; Campbell, Fiona; Costello, Eithne; H. Lloyd, Bryony; M. Copple, Ian; Williams, Samantha; Owen, Andrew; P. Neoptolemos, John; E. Goldring, Christopher; Kevin Park, B.

doi:10.1186/1476-4598-10-37

Public

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

Published in Molecular Cancer • Apr 13, 2011

Authors:

Adam Lister

Taoufik Nedjadi

Neil R. Kitteringham

Abstract

BACKGROUND: Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for proteasomal degradation. The Nrf2/Keap1 system is dysregulated in lung, head and nec...

Subject

KEAP1

Pancreatic cancer

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!