Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

V. Britanova, Olga; V. Putintseva, Ekaterina; Shugay, Mikhail; M. Merzlyak, Ekaterina; A. Turchaninova, Maria; B. Staroverov, Dmitriy; A. Bolotin, Dmitriy; Lukyanov, Sergey; А. Богданова, Е.; Z. Mamedov, Ilgar; B. Lebedev, Yuri; M. Chudakov, Dmitriy

doi:10.4049/jimmunol.1302064

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Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

Published in The Journal of Immunology • Feb 8, 2014

Authors:

Olga V. Britanova

Ekaterina V. Putintseva

Mikhail Shugay

Abstract

The decrease of TCR diversity with aging has never been studied by direct methods. In this study, we combined high-throughput Illumina sequencing with unique cDNA molecular identifier technology to achieve deep and precisely normalized profiling of TCR β repertoires in 39 healthy donors aged 6-90 y....

Subject

Repertoire

Profiling (computer programming)

Evolutionary biology

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