NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

Ito, Mamoru; Hiramatsu, Hidefumi; Kobayashi, Kimio; Suzue, Kazutomo; Kawahata, Mariko; Hioki, Kyoji; Ueyama, Yoshito; Koyanagi, Yoshio; Sugamura, Kazuo; Tsuji, Kohichiro; Heike, Toshio; Nakahata, Tatsutoshi

doi:10.1182/blood-2001-12-0207

Public

NOD/SCID/γcnull mouse: an excellent recipient mouse model for engraftment of human cells

Published in Blood • Oct 16, 2002

Authors:

Mamoru Ito

Hidefumi Hiramatsu

Kimio Kobayashi

Abstract

To establish a more appropriate animal recipient for xenotransplantation, NOD/SCID/gamma(c)(null) mice double homozygous for the severe combined immunodeficiency (SCID) mutation and interleukin-2Rgamma (IL-2Rgamma) allelic mutation (gamma(c)(null)) were generated by 8 backcross matings of C57BL/6J-g...

Subject

Nod

Severe combined immunodeficiency

Biology

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