Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, Siân; Zhang, Xiaosong; Williams Parsons, D.; Lin, Jimmy; Leary, Rebecca; Angenendt, Philipp; K. Mankoo, Parminder; Carter, Hannah; Kamiyama, Hirohiko; Jimeno, Antonio; Hong, Seung‐Mo; Fu, Baojin; Lin, Ming‐Tseh; S. Calhoun, Eric; Kamiyama, Mihoko; Walter, Kimberly; Nikolskaya, Tatiana; Nikolsky, Yuri; Hartigan, James; R. Smith, Douglas; Hidalgo, Manuel; D. Leach, Steven; P. Klein, Alison; M. Jaffee, Elizabeth; Goggins, Michael; Maitra, Anirban; A. Iacobuzio–Donahue, Christine; R. Eshleman, James; E. Kern, Scott; H. Hruban, Ralph; Karchin, Rachel; Papadopoulos, Nickolas; Parmigiani, Giovanni; Vogelstein, Bert; E. Velculescu, Victor; W. Kinzler, Kenneth

doi:10.1126/science.1164368

Public

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Published in Science • Sep 4, 2008

Authors:

Siân Jones

Xiaosong Zhang

D. Williams Parsons

Abstract

There are currently few therapeutic options for patients with pancreatic cancer, and new insights into the pathogenesis of this lethal disease are urgently needed. Toward this end, we performed a comprehensive genetic analysis of 24 pancreatic cancers. We first determined the sequences of 23,219 tra...

Subject

Biology

Carcinogenesis

Pancreatic cancer

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