Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation.

X, Shi; X, Chen; X, Li; X, Lan; C, Zhao; S, Liu; H, Huang; N, Liu; S, Liao; W, Song; P, Zhou; S, Wang; L, Xu; X, Wang; QP, Dou; J, Liu

doi:10.1158/1078-0432.ccr-13-1063

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Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation.

Shared by NobleBlocks on Dec 12, 2013 • 12:00 AM UTC

Authors:

Shi X

Chen X

Li X

Abstract

Purpose Chronic myelogenous leukemia (CML) is characterized by the constitutive activation of Bcr-Abl tyrosine kinase. Bcr-Abl-T315I is the predominant mutation that causes resistance to imatinib, cytotoxic drugs, and the second-generation tyrosine kinase inhibitors. The emergence of imatinib resist...

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