Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome

S. Legro, Richard; X. Barnhart, Huiman; D. Schlaff, William; R. Carr, Bruce; P. Diamond, Michael; Ann Carson, Sandra; P. Steinkampf, Michael; Coutifaris, Christos; G. McGovern, Peter; A. Cataldo, Nicholas; G. Gosman, Gabriella; E. Nestler, John; C. Giudice, Linda; C. Leppert, Phyllis; R. Myers, Evan

doi:10.1056/nejmoa063971

Public

Clomiphene, Metformin, or Both for Infertility in the Polycystic Ovary Syndrome

Published in New England Journal of Medicine • Feb 7, 2007

Authors:

Richard S. Legro

Huiman X. Barnhart

William D. Schlaff

Abstract

BACKGROUND: The polycystic ovary syndrome is a common cause of infertility. Clomiphene and insulin sensitizers are used alone and in combination to induce ovulation, but it is unknown whether one approach is superior. METHODS: We randomly assigned 626 infertile women with the polycystic ovary syndro...

Subject

Polycystic ovary

Metformin

Medicine

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