Epidermal Growth Factor Receptor in Non–Small-Cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis

R. Hirsch, Fred; Varella‐Garcia, Marileila; A. Bunn, Paul; V. Di Maria, Michael; Veve, Robert; M. Bremnes, Roy; E. Barón, Anna; Zeng, Chan; A. Franklin, Wilbur

doi:10.1200/jco.2003.11.069

Public

Epidermal Growth Factor Receptor in Non–Small-Cell Lung Carcinomas: Correlation Between Gene Copy Number and Protein Expression and Impact on Prognosis

Published in Journal of Clinical Oncology • Sep 9, 2003

Authors:

Fred R. Hirsch

Marileila Varella‐Garcia

Paul A. Bunn

Abstract

PURPOSE: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. The molecular mechanisms responsible for EGFR overexpression are poorly understood. MATERIALS AND METHODS: Gene copy nu...

Subject

Polysomy

Epidermal growth factor receptor

Copy-number variation

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