Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway

Liu, Chunfang; Zhang, Yanqiong; Kong, Xiangying; Zhu, Liuluan; Pang, Jian; Xu, Ying; Chen, Weiheng; Zhan, Hongsheng; Lü, Aiping; Lin, Na

doi:10.1155/2013/626038

Public

Triptolide Prevents Bone Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis by Targeting RANKL/RANK/OPG Signal Pathway

Published in Evidence-based Complementary and Alternative Medicine • Jan 1, 2013

Authors:

Chunfang Liu

Yanqiong Zhang

Xiangying Kong

Abstract

Focal bone destruction within inflamed joints is the most specific hallmark of rheumatoid arthritis (RA). Our previous study indicated that the therapeutic efficiency of triptolide in RA may be due partially to its chondroprotective and anti-inflammatory effects. However, its roles in bone destructi...

Subject

RANKL

Triptolide

Osteoprotegerin

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