Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

Taly, Valérie; Pekin, Deniz; Benhaïm, Léonor; K. Kotsopoulos, Steve; Le Corre, Delphine; Li, Xinyu; Atochin, Ivan; R. Link, Darren; D. Griffiths, Andrew; Pallier, Karine; Blons, Hélène; Bouché, Olivier; Landi, Bruno; Brian Hutchison, J.; Laurent‐Puig, Pierre

doi:10.1373/clinchem.2013.206359

Public

Multiplex Picodroplet Digital PCR to Detect KRAS Mutations in Circulating DNA from the Plasma of Colorectal Cancer Patients

Published in Clinical Chemistry • Aug 12, 2013

Authors:

Valérie Taly

Deniz Pekin

Léonor Benhaïm

Abstract

BACKGROUND: Multiplex digital PCR (dPCR) enables noninvasive and sensitive detection of circulating tumor DNA with performance unachievable by current molecular-detection approaches. Furthermore, picodroplet dPCR facilitates simultaneous screening for multiple mutations from the same sample. METHODS...

Subject

KRAS

Digital polymerase chain reaction

Multiplex

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