SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors.

Horbal, Liliya; Rebets, Yuriy; Rabyk, Mariya; Makitrynskyy, Roman; Luzhetskyy, Andriy; Fedorenko, Victor; Bechthold, Andreas

doi:10.1186/2191-0855-2-1

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SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors.

Shared by NobleBlocks on Jan 3, 2012 • 12:00 AM UTC

Authors:

Liliya Horbal

Yuriy Rebets

Mariya Rabyk

Abstract

Analysis of the simocyclinone biosynthesis (sim) gene cluster of Streptomyces antibioticus Tü6040 led to the identification of a putative pathway specific regulatory gene simReg1. In silico analysis places the SimReg1 protein in the OmpR-PhoB subfamily of response regulators. Gene replacement of sim...

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