IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

L Doyle, Sarah; Ozaki, Ema; Brennan, Kiva; M Humphries, Marian; Mulfaul, Kelly; Keaney, James; F Kenna, Paul; Maminishkis, Arvydas; Kiang, Anna-Sophia; P Saunders, Sean; Hams, Emily; C Lavelle, Ed; Gardiner, Clair; G Fallon, Padraic; Adamson, Peter; Humphries, Peter; Campbell, Matthew

doi:10.1126/scitranslmed.3007616

Public

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Shared by NobleBlocks on Apr 2, 2014 • 12:00 AM UTC

Authors:

Sarah L Doyle

Ema Ozaki

Kiva Brennan

Abstract

Age-related macular degeneration (AMD) is the most common form of central retinal blindness globally. Distinct processes of the innate immune system, specifically activation of the NLRP3 inflammasome, have been shown to play a central role in the development of both "dry" and neovascular ("wet") for...

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