Structure and Function of the Polymeric Mucins in Airways Mucus

J. Thornton, David; Rousseau, Karine; A. McGuckin, Michael

doi:10.1146/annurev.physiol.70.113006.100702

Public

Structure and Function of the Polymeric Mucins in Airways Mucus

Published in Annual Review of Physiology • Sep 12, 2007

Authors:

David J. Thornton

Karine Rousseau

Michael A. McGuckin

Abstract

The airways mucus gel performs a critical function in defending the respiratory tract against pathogenic and environmental challenges. In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUC5B, provide the organizing framework of the airways mucus gel and are maj...

Subject

Mucin

Mucus

Cystic fibrosis

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