Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Nishizato, Yohei

doi:10.1016/s0009-9236(03)00060-2

Public

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Published in Clinical Pharmacology & Therapeutics • Jun 1, 2003

Authors:

Yohei Nishizato

Abstract

OBJECTIVE: Our objective was to quantitate the contribution of the genetic polymorphisms of the genes for 2 human organic anion transporters-organic anion transporting polypeptide C (OATP-C) and organic anion transporter 3 (OAT3)-to the pharmacokinetics of pravastatin. METHODS: Genetic polymorphisms...

Subject

Organic anion-transporting polypeptide

Nonsynonymous substitution

Organic anion transporter 1

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