MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Fasanaro, Pasquale; D’Alessandra, Yuri; Di Stefano, Valeria; Melchionna, Roberta; Romani, Sveva; Pompilio, Giulio; C. Capogrossi, Maurizio; Martelli, Fabio

doi:10.1074/jbc.m800731200

Public

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Published in Journal of Biological Chemistry • Apr 17, 2008

Authors:

Pasquale Fasanaro

Yuri D’Alessandra

Valeria Di Stefano

Abstract

MicroRNAs (miRNAs) are small non-protein-coding RNAs that function as negative gene expression regulators. In the present study, we investigated miRNAs role in endothelial cell response to hypoxia. We found that the expression of miR-210 progressively increased upon exposure to hypoxia. miR-210 over...

Subject

Cell biology

microRNA

Biology

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