The Transcriptional Activator GCN4 Contains Multiple Activation Domains That Are Critically Dependent on Hydrophobic Amino Acids

M. Drysdale, Connie; Dueñas, Encarnación; M. Jackson, Belinda; Reusser, Ueli; H. Braus, Gerhard; G. Hinnebusch, Alan

doi:10.1128/mcb.15.3.1220

Public

The Transcriptional Activator GCN4 Contains Multiple Activation Domains That Are Critically Dependent on Hydrophobic Amino Acids

Published in Molecular and Cellular Biology • Mar 1, 1995

Authors:

Connie M. Drysdale

Encarnación Dueñas

Belinda M. Jackson

Abstract

GCN4 is a transcriptional activator in the bZIP family that regulates amino acid biosynthetic genes in the yeast Saccharomyces cerevisiae. Previous work suggested that the principal activation domain of GCN4 is a highly acidic segment of approximately 40 amino acids located in the center of the prot...

Subject

Biology

Amino acid

Saccharomyces cerevisiae

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