Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays

Jain, Nitin; Thatte, Jayant; J. Braciale, Thomas; Ley, Klaus; J. O’Connell, Michael; K. Lee, Jae

doi:10.1093/bioinformatics/btg264

Public

Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays

Published in Bioinformatics • Oct 10, 2003

Authors:

Nitin Jain

Jayant Thatte

Thomas J. Braciale

Abstract

MOTIVATION: In microarray studies gene discovery based on fold-change values is often misleading because error variability for each gene is heterogeneous under different biological conditions and intensity ranges. Several statistical testing methods for differential gene expression have been suggest...

Subject

Pooling

Replicate

DNA microarray

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