<scp>MiR</scp>‐124 Regulates Apoptosis and Autophagy Process in <scp>MPTP</scp> Model of <scp>P</scp>arkinson's Disease by Targeting to <scp>B</scp>im

Wang, Huiqing; Ye, Yongyi; Zhu, Zhiyuan; Mo, Liqian; Lin, Chun‐Nan; Wang, Qifu; Wang, Haoyuan; Gong, Xin; He, Xiaozheng; Lu, Guohui; Lu, Fengfei; Zhang, Shizhong

doi:10.1111/bpa.12267

Public

MiR‐124 Regulates Apoptosis and Autophagy Process in MPTP Model of Parkinson's Disease by Targeting to Bim

Published in Brain Pathology • May 15, 2015

Authors:

Huiqing Wang

Yongyi Ye

Zhiyuan Zhu

Abstract

Parkinson's disease (PD) is the most prevalent movement disorder characterized by selective loss of midbrain dopaminergic (DA) neurons. MicroRNA-124 (miR-124) is abundantly expressed in the DA neurons and its expression level decreases in the 1-methyl-4-pheny-1, 2, 3, 6-tetrahydropyridine (MPTP) mod...

Subject

MPTP

Downregulation and upregulation

Autophagy

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