Statins Upregulate <i>PCSK9</i> , the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

Dubuc, Geneviève; Chamberland, Ann; Wassef, Hanny; Davignon, Jean; G. Seidah, Nabil; Bernier, Lise; Prat, Annik

doi:10.1161/01.atv.0000134621.14315.43

Public

Statins Upregulate PCSK9 , the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

Published in Arteriosclerosis Thrombosis and Vascular Biology • Jun 8, 2004

Authors:

Geneviève Dubuc

Ann Chamberland

Hanny Wassef

Abstract

OBJECTIVE: Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of protein precursors. The NARC-1 gene, PCSK9, has been identified recently as the third locus implicated in autosomal dominant hypercholesterole...

Subject

PCSK9

LDL receptor

Proprotein convertase

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