Statins Upregulate
                    <i>PCSK9</i>
                    , the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

Dubuc, Geneviève; Chamberland, Ann; Wassef, Hanny; Davignon, Jean; G. Seidah, Nabil; Bernier, Lise; Prat, Annik

doi:10.1161/01.atv.0000134621.14315.43

Public

Statins Upregulate PCSK9 , the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

Shared by NobleBlocks on Aug 1, 2004 • 12:00 AM UTC

Authors:

Geneviève Dubuc

Ann Chamberland

Hanny Wassef

Abstract

Objective— Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the proprotein convertase family implicated in the cleavage of a variety of protein precursors. The NARC-1 gene, PCSK9 , has been identified recently as the third locus implicated in autosomal dominant hypercholesterol...

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