Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)

Greijer, A.E.; van der Groep, Petra; Kemming, Dirk; Шварц, Анна; Semenza, GL; A. Meijer, Gerrit; A. van de Wiel, Mark; Belien, JAM; van Diest, PJ; van der Wall, Elsken

doi:10.1002/path.1778

Public

Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)

Published in The Journal of Pathology • May 19, 2005

Authors:

A.E. Greijer

Petra van der Groep

Dirk Kemming

Abstract

The hypoxia-inducible factor 1 (HIF-1) plays a critical role in cellular responses to hypoxia. The aim of the present study was to evaluate which genes are induced by hypoxia, and whether this induction is mediated by HIF-1, by expression microarray analysis of wt and HIF-1alpha null mouse fibroblas...

Subject

Biology

Gene

Hypoxia (environmental)

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