IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice

Wakashin, Hidefumi; Hirose, Koichi; Maezawa, Yuko; Kagami, Shin‐ichiro; Suto, Akira; Watanabe, Norihiko; Saito, Yasushi; Hatano, Masahiko; Tokuhisa, Takeshi; Iwakura, Yoichiro; Puccetti, Paolo; Iwamoto, Itsuo; Nakajima, Hiroshi

doi:10.1164/rccm.200801-086oc

Public

IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice

Published in American Journal of Respiratory and Critical Care Medicine • Sep 11, 2008

Authors:

Hidefumi Wakashin

Koichi Hirose

Yuko Maezawa

Abstract

RATIONALE: The IL-23-IL-17A-producing CD4(+) T-cell (Th17 cell) axis plays an important role in the development of chronic inflammatory diseases, including autoimmune diseases. However, the role of the IL-23-Th17 cell axis in the regulation of allergic airway inflammation is still largely unknown. O...

Subject

Eosinophil

Immunology

Medicine

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