Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

N. A. Hussain, Sabah; Mofarrahi, Mahroo; Sigala, Ioanna; Cheol Kim, Ho; Vassilakopoulos, Theodoros; Maltais, François; Bellenis, Ion; Chaturvedi, Rakesh; B. Gottfried, Stewart; Metrakos, Peter; Danialou, Gawiyou; Matecki, Stéfan; Jaber, Samir; J. Petrof, Basil; Goldberg, Peter

doi:10.1164/rccm.201002-0234oc

Public

Mechanical Ventilation–induced Diaphragm Disuse in Humans Triggers Autophagy

Published in American Journal of Respiratory and Critical Care Medicine • Jul 16, 2010

Authors:

Sabah N. A. Hussain

Mahroo Mofarrahi

Ioanna Sigala

Abstract

RATIONALE: Controlled mechanical ventilation (CMV) results in atrophy of the human diaphragm. The autophagy-lysosome pathway (ALP) contributes to skeletal muscle proteolysis, but its contribution to diaphragmatic protein degradation in mechanically ventilated patients is unknown. OBJECTIVES: To eval...

Subject

Autophagy

FOXO1

Protein kinase B

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