Detection of Mutations in <i>EGFR</i> in Circulating Lung-Cancer Cells

Maheswaran, Shyamala; V. Sequist, Lecia; Nagrath, Sunitha; Ulkus, Lindsey; W. Brannigan, Brian; V. Collura, Chey; K. Inserra, Elizabeth; Diederichs, Sven; John Iafrate, A.; W. Bell, Daphne; R. Digumarthy, Subba; Muzikansky, Alona; Irimia, Daniel; Settleman, Jeffrey; G. Tompkins, Ronald; J. Lynch, Thomas; Toner, Mehmet; A. Haber, Daniel

doi:10.1056/nejmoa0800668

Public

Detection of Mutations in EGFR in Circulating Lung-Cancer Cells

Published in New England Journal of Medicine • Jul 2, 2008

Authors:

Shyamala Maheswaran

Lecia V. Sequist

Sunitha Nagrath

Abstract

BACKGROUND: The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non-small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of circulating tumor cells may provide a strateg...

Subject

Medicine

Lung cancer

Mutation

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