Cell-free DNA Analysis for Noninvasive Examination of Trisomy

E. Norton, Mary; Jacobsson, Bo; K. Swamy, Geeta; C. Laurent, Louise; C. Ranzini, Angela; Brar, Herb; W. Tomlinson, Mark; Pereira, Leonardo; Lea Spitz, Jean; Hollemon, Desiree; Cuckle, Howard; J. Musci, Thomas; J. Wapner, Ronald

doi:10.1056/nejmoa1407349

Public

Cell-free DNA Analysis for Noninvasive Examination of Trisomy

Published in New England Journal of Medicine • Apr 2, 2015

Authors:

Mary E. Norton

Bo Jacobsson

Geeta K. Swamy

Abstract

BACKGROUND: Cell-free DNA (cfDNA) testing for fetal trisomy is highly effective among high-risk women. However, there have been few direct, well-powered studies comparing cfDNA testing with standard screening during the first trimester in routine prenatal populations. METHODS: In this prospective, m...

Subject

Medicine

Trisomy

Cell-free fetal DNA

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