Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

Sun, Wujin; Ji, Wenyan; M. Hall, Jordan; Hu, Quanyin; Wang, Chao; L. Beisel, Chase; Gu, Zhen

doi:10.1002/anie.201506030

Public

Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

Published in Angewandte Chemie International Edition • Aug 27, 2015

Authors:

Wujin Sun

Wenyan Ji

Jordan M. Hall

Abstract

CRISPR-Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that simultaneously delivers the Cas9 protein and single guide RNA (sgRNA) is based on DNA nanoclews, yarn-like DNA nanoparticles that are synthe...

Subject

Cas9

CRISPR

Subgenomic mRNA

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