Insight into the molecular basis of pathogen abundance: Group A <i>Streptococcus</i> inhibitor of complement inhibits bacterial adherence and internalization into human cells

P. Hoe, Nancy; Ireland, Robin; R. DeLeo, Frank; B. Gowen, Brian; W. Dorward, David; M. Voyich, Jovanka; Liu, Mengyao; H. Burns, Eugene; M. Culnan, Derek; Bretscher, Anthony; M. Musser, James

doi:10.1073/pnas.112039899

Public

Insight into the molecular basis of pathogen abundance: Group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cells

Published in Proceedings of the National Academy of Sciences • May 21, 2002

Authors:

Nancy P. Hoe

Robin Ireland

Frank R. DeLeo

Abstract

Streptococcal inhibitor of complement (Sic) is a secreted protein made predominantly by serotype M1 Group A Streptococcus (GAS), which contributes to persistence in the mammalian upper respiratory tract and epidemics of human disease. Unexpectedly, an isogenic sic-negative mutant adhered to human ep...

Subject

Internalization

Ezrin

Biology

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