Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis

Costet, Philippe; Legendre, Christiane; Moré, Jean; D. Edgar, Alan; Galtier, P.; Pineau, Thierry

doi:10.1074/jbc.273.45.29577

Public

Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis

Published in Journal of Biological Chemistry • Nov 1, 1998

Authors:

Philippe Costet

Christiane Legendre

Jean Moré

Abstract

The alpha-isoform of the peroxisome proliferator-activated receptor (PPARalpha) is a nuclear transcription factor activated by structurally diverse chemicals referred to as peroxisome proliferators. Activators can be endogenous molecules (fatty acids/steroids) or xenobiotics (fibrate lipid-lowering ...

Subject

Endocrinology

Internal medicine

Biology

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