BG9719 (CVT-124), an A <sub>1</sub> Adenosine Receptor Antagonist, Protects Against the Decline in Renal Function Observed With Diuretic Therapy

S. Gottlieb, Stephen; Craig Brater, D.; Thomas, Ignatius; P. Havranek, Edward; C. Bourge, Robert; Goldman, Steven; Dyer, Farere; Salvador Gomez, M.Transito; Bennett, Donald; Ticho, Barry; Beckman, Evan; T. Abraham, William

doi:10.1161/hc1102.105264

Public

BG9719 (CVT-124), an A 1 Adenosine Receptor Antagonist, Protects Against the Decline in Renal Function Observed With Diuretic Therapy

Published in Circulation • Mar 19, 2002

Authors:

Stephen S. Gottlieb

D. Craig Brater

Ignatius Thomas

Abstract

BACKGROUND: Adenosine may adversely affect renal function via its effects on renal arterioles and tubuloglomerular feedback, but effects of adenosine blockade in humans receiving furosemide and ACE inhibitors is unknown. METHODS AND RESULTS: This was a randomized, double-blind, ascending-dose, cross...

Subject

Furosemide

Medicine

Renal function

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