MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

P. Treon, Steven; Xu, Lian; Yang, Guang; Zhou, Yangsheng; Liu, Xia; Cao, Yang; Sheehy, Patricia; Manning, Robert; J. Patterson, Christopher; Tripsas, Christina; Arcaini, Luca; S. Pinkus, Geraldine; J. Rodig, Scott; R. Sohani, Aliyah; L. Harris, Nancy; M. Laramie, Jason; A. Skifter, Donald; E. Lincoln, Stephen; R. Hunter, Zachary

doi:10.1056/nejmoa1200710

Public

MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia

Published in New England Journal of Medicine • Aug 29, 2012

Authors:

Steven P. Treon

Lian Xu

Guang Yang

Abstract

BACKGROUND: Waldenström's macroglobulinemia is an incurable, IgM-secreting lymphoplasmacytic lymphoma (LPL). The underlying mutation in this disorder has not been delineated. METHODS: We performed whole-genome sequencing of bone marrow LPL cells in 30 patients with Waldenström's macroglobulinemia, w...

Subject

Waldenstrom macroglobulinemia

Macroglobulinemia

Lymphoplasmacytic Lymphoma

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