Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation

Yi, Ping; Melnyk, Stepan; Pogribna, Marta; P. Pogribny, Igor; Jean Hine, R.; Jill James, S.

doi:10.1074/jbc.m002725200

Public

Increase in Plasma Homocysteine Associated with Parallel Increases in Plasma S-Adenosylhomocysteine and Lymphocyte DNA Hypomethylation

Published in Journal of Biological Chemistry • Sep 1, 2000

Authors:

Ping Yi

Stepan Melnyk

Marta Pogribna

Abstract

S-Adenosylmethionine and S-adenosylhomocysteine (SAH), as the substrate and product of essential cellular methyltransferase reactions, are important metabolic indicators of cellular methylation status. Chronic elevation of SAH, secondary to the homocysteine-mediated reversal of the SAH hydrolase rea...

Subject

Methyltransferase

Methylation

DNA methylation

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