L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA

Angela Cenci, M.; S. Lee, C.; Björklund, Anders

doi:10.1046/j.1460-9568.1998.t01-1-00285.x

Public

L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA

Published in European Journal of Neuroscience • Aug 1, 1998

Authors:

M. Angela Cenci

C. S. Lee

Anders Björklund

Abstract

Rats sustaining unilateral near-complete 6-hydroxydopamine lesions of the mesostriatal dopamine pathway received daily injections of 3, 4 dihydroxyphenyl-l-alanine (L-DOPA, 8 mg/kg plus 15 mg/kg benserazide) for 3 weeks. During this period, about 50% of the rats gradually developed abnormal involunt...

Subject

Dynorphin

Dyskinesia

Benserazide

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