Virtual Screening for Submicromolar Leads of tRNA-guanine Transglycosylase Based on a New Unexpected Binding Mode Detected by Crystal Structure Analysis

Brenk, Ruth; Nærum, Lars; Grädler, Ulrich; Gerber, Hans‐Dieter; A. Garcia, George; Reuter, Klaus; T. Stubbs, Milton; Klebe, G.

doi:10.1021/jm0209937

Public

Virtual Screening for Submicromolar Leads of tRNA-guanine Transglycosylase Based on a New Unexpected Binding Mode Detected by Crystal Structure Analysis

Published in Journal of Medicinal Chemistry • Feb 22, 2003

Authors:

Ruth Brenk

Lars Nærum

Ulrich Grädler

Abstract

Eubacterial tRNA-guanine transglycosylase (TGT) is involved in the hypermodification of cognate tRNAs, leading to the exchange of G34 by preQ1 at the wobble position in the anticodon loop. Mutation of the tgt gene in Shigella flexneri results in a significant loss of pathogenicity of the bacterium d...

Subject

Chemistry

Transfer RNA

Pharmacophore

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