<i>PDGFRA</i>
                    Activating Mutations in Gastrointestinal Stromal Tumors

C. Heinrich, Michael; L. Corless, Christopher; Duensing, Anette; McGreevey, Laura; Chen, Chang-Jie; Joseph, Nora; Singer, Samuel; J. Griffith, Diana; Haley, Andrea; Town, Ajia; D. Demetri, George; D. M. Fletcher, Christopher; A. Fletcher, Jonathan

doi:10.1126/science.1079666

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PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors

Shared by NobleBlocks on Jan 28, 2003 • 12:00 AM UTC

Authors:

Michael C. Heinrich

Christopher L. Corless

Anette Duensing

Abstract

Most gastrointestinal stromal tumors (GISTs) have activating mutations in the KIT receptor tyrosine kinase, and most patients with GISTs respond well to Gleevec, which inhibits KIT kinase activity. Here we show that ∼35% (14 of 40) of GISTs lacking KIT mutations have intragenic activation mutations ...

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