Functional Characterization of Src-interacting Na/K-ATPase Using RNA Interference Assay

Liang, Man; Cai, Ting; Tian, Jiang; Qu, Weikai; Xie, Zijian

doi:10.1074/jbc.m512240200

Public

Functional Characterization of Src-interacting Na/K-ATPase Using RNA Interference Assay

Published in Journal of Biological Chemistry • May 13, 2006

Authors:

Man Liang

Ting Cai

Jiang Tian

Abstract

We have shown that the Na/K-ATPase and Src form a signaling receptor complex. Here we determined how alterations in the amount and properties of the Na/K-ATPase affect basal Src activity and ouabain-induced signal transduction. Several alpha1 subunit knockdown cell lines were generated by transfecti...

Subject

Proto-oncogene tyrosine-protein kinase Src

RNA interference

ATPase

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