Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Saeed, Sadia; Quintin, Jessica; H. D. Kerstens, Hindrik; Rao, Nagesha; Aghajanirefah, Ali; Matarese, Filomena; Cheng, Shih‐Chin; M. Ratter, Jacqueline; Berentsen, Kim; A. van der Ent, Martijn; Sharifi, Nilofar; M. Janssen‐Megens, Eva; ter Huurne, Menno; Mandoli, Amit; van Schaik, Tom; Ng, Aylwin; Burden, Frances; Downes, Kate; Frontini, Mattia; Kumar, Vinod; J. Giamarellos‐Bourboulis, Evangelos; H. Ouwehand, Willem; van der Meer, J.W.M.; A. B. Joosten, Leo; Wijmenga, Cisca; H.A. Martens, Joost; J. Xavier, Ramnik; Logie, Colin; G. Netea, Mihai; G. Stunnenberg, Hendrik

doi:10.1126/science.1251086

Public

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Published in Science • Sep 25, 2014

Authors:

Sadia Saeed

Jessica Quintin

Hindrik H. D. Kerstens

Abstract

Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. We characterized the transcriptomes a...

Subject

Epigenetics

Biology

Innate immune system

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