Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

von Bernuth, Horst; Pïcard, Capucine; Jin, Zhongbo; Pankla, Rungnapa; Xiao, Hui; Ku, Cheng‐Lung; Chrabieh, Maya; Ben‐Mustapha, Imen; Ghandil, Pegah; Çamcıoğlu, Yıldız; Vasconcelos, Julia; Sirvent, Nicolas; Guedes, Margarida; Bonito Vítor, Artur; J. Herrero‐Mata, M.; I. Aróstegui, Juan; Rodrigo, Carlos; Alsina, Laia; Ruiz‐Ortiz, Estíbaliz; Juan, Manel; Fortuny, Clàudia; Yagüe, Jordi; Antón, Jordi; Pascal, Mariona; Chang, Huey-Hsuan; Jannière, Lucile; Rose, Y; Garty, Ben-Zion; Chapel, Helen; C. Issekutz, Andrew; Maródi, László; Rodríguez‐Gallego, Carlos; Banchereau, Jacques; Abel, Laurent; Li, Xiaoxia; Chaussabel, Damien; Puel, Anne; Casanova, Jean‐Laurent

doi:10.1126/science.1158298

Public

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

Published in Science • Jul 31, 2008

Authors:

Horst von Bernuth

Capucine Pïcard

Zhongbo Jin

Abstract

MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs). MyD88 deficiency in mice leads to susceptibility to a broad range of pathogens in experimental settings of infection. We describe a distinct situation in a natural setting of human infection. ...

Subject

Immunology

Immunity

Receptor

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