Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

Takayanagi, Hiroshi; Iizuka, Hideharu; Juji, Takuo; Nakagawa, Takumi; Yamamoto, Aiichiro; Miyazaki, Tsuyoshi; Koshihara, Yasuko; Oda, Hiromi; Nakamura, Kozo; Tanaka, Sakae

doi:10.1002/1529-0131(200002)43:2<259::aid-anr4>3.0.co;2-w

Public

Involvement of receptor activator of nuclear factor κB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

Published in Arthritis & Rheumatism • Feb 1, 2000

Authors:

Hiroshi Takayanagi

Hideharu Iizuka

Takuo Juji

Abstract

OBJECTIVE: To clarify the mechanism by which osteoclasts are formed in culture of rheumatoid synoviocytes by exploring the involvement of receptor activator of nuclear factor kappaB ligand (RANKL)/osteoclast differentiation factor (ODF). METHODS: Osteoclast formation was evaluated in cocultures of r...

Subject

RANKL

Osteoclast

Osteoprotegerin

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