Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Cinti, Saverio; A. Mitchell, Grant; Barbatelli, Giorgio; Murano, Incoronata; Ceresi, E; Faloia, Emanuela; Wang, Shupei; Fortier, Mélanie; S. Greenberg, Andrew; S. Obin, Martin

doi:10.1194/jlr.m500294-jlr200

Public

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

Published in Journal of Lipid Research • Sep 9, 2005

Authors:

Saverio Cinti

Grant A. Mitchell

Giorgio Barbatelli

Abstract

Macrophage infiltration of white adipose tissue (WAT) is implicated in the metabolic complications of obesity. The precipitating event(s) and function(s) of macrophage infiltration into WAT are unknown. We demonstrate that >90% of all macrophages in WAT of obese mice and humans are localized to dead...

Subject

Adipocyte

Adipose tissue

Macrophage

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