A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Grynkiewicz, Grzegorz; Poenie, Martin; Y. Tsien, Roger

doi:10.1016/s0021-9258(19)83641-4

Public

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Published in Journal of Biological Chemistry • Mar 1, 1985

Authors:

Grzegorz Grynkiewicz

Martin Poenie

Roger Y. Tsien

Abstract

A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+. The compounds combine an 8-coordinate tetracarboxylate chelating site with stilbene chromophores. Incorporation of the ethylenic linkage of the stilbene into a...

Subject

Fluorescence

Chemistry

Biophysics

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