S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis

Gopal, Radha; Monin, Leticia; Torres‐García, Diana; Slight, Samantha; Mehra, Smriti; C. McKenna, Kyle; A. Fallert Junecko, Beth; A. Reinhart, Todd; K. Kolls, Jay; Báez-Saldaña, Renata; Cruz‐Lagunas, Alfredo; Sofia Rodrı́guez-Reyna, Tatiana; Pavan Kumar, Nathella; Tessier, P.; Roth, Johannes; Selman, Moisés; Becerril‐Villanueva, Enrique; Baquera‐Heredia, Javier; M. Cumming, Bridgette; Kasprowicz, Victoria; J. C. Steyn, Adrie; Babu, Subash; Kaushal, Deepak; Zúñiga, Joaquı́n; Vogl, Thomas; Rangel‐Moreno, Javier; A. Khader, Shabaana

doi:10.1164/rccm.201304-0803oc

Public

S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis

Published in American Journal of Respiratory and Critical Care Medicine • Sep 18, 2013

Authors:

Radha Gopal

Leticia Monin

Diana Torres‐García

Abstract

RATIONALE: A hallmark of pulmonary tuberculosis (TB) is the formation of granulomas. However, the immune factors that drive the formation of a protective granuloma during latent TB, and the factors that drive the formation of inflammatory granulomas during active TB, are not well defined. OBJECTIVES...

Subject

Inflammation

Immunology

Chemokine

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