Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.

JP, Mira; A, Cariou; F, Grall; C, Delclaux; MR, Losser; F, Heshmati; C, Cheval; M, Monchi; JL, Teboul; F, Riché; G, Leleu; L, Arbibe; A, Mignon; M, Delpech; JF, Dhainaut

doi:10.1001/jama.282.6.561

Public

Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.

Shared by NobleBlocks on Aug 1, 1999 • 12:00 AM UTC

Authors:

Mira JP

Cariou A

Grall F

Abstract

Context Tumor necrosis factor alpha (TNF-alpha) is believed to be a cytokine central to pathogenesis of septic shock. TNF2, a polymorphism within the TNF-alpha gene promoter, has been associated with enhanced TNF-alpha production and negative outcome in some severe infections.Objectives To investiga...

Discussions