An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies

Bartosch, Birke; Verney, Géraldine; Dreux, Marlène; Donot, Peggy; Morice, Yoann; Penin, François; Pawlotsky, Jean-Michel; Lavillette, Dimitri; Cosset, Francois-Loïc

doi:10.1128/jvi.79.13.8217-8229.2005

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An Interplay between Hypervariable Region 1 of the Hepatitis C Virus E2 Glycoprotein, the Scavenger Receptor BI, and High-Density Lipoprotein Promotes both Enhancement of Infection and Protection against Neutralizing Antibodies

Shared by NobleBlocks on Jul 1, 2005 • 12:00 AM UTC

Authors:

Birke Bartosch

Géraldine Verney

Marlène Dreux

Abstract

ABSTRACT Hepatitis C virus (HCV) circulates in the bloodstream in different forms, including complexes with immunoglobulins and/or lipoproteins. To address the significance of such associations, we produced or treated HCV pseudoparticles (HCVpp), a valid model of HCV cell entry and its inhibition, w...

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