Cisplatin and Fluorouracil Alone or with Docetaxel in Head and Neck Cancer

R. Posner, Marshall; Hershock, Diáne; Blajman, C.; Mickiewicz, E.; Winquist, Eric; Gorbounova, Vera; Tjulandin, Sergei; M. Shin, Dong; J. Cullen, Kevin; J. Ervin, Thomas; A. Murphy, Barbara; E. Raez, Luis; B. Cohen, Roger; B. Spaulding, Monica; B. Tishler, Roy; Roth, Berta; del Carmen Viroglio, Rosana; Venkatesan, Varagur; С. Романов, И.; S. Agarwala, Sanjiv; William Harter, K.; Dugan, Matthew; J. Cmelak, Anthony; M. Markoe, Arnold; W. Read, Paul; M. Steinbrenner, Lynn; Dimitrios Colevas, A.; M. Norris, Charles; I. Haddad, Robert

doi:10.1056/nejmoa070956

Public

Cisplatin and Fluorouracil Alone or with Docetaxel in Head and Neck Cancer

Published in New England Journal of Medicine • Oct 24, 2007

Authors:

Marshall R. Posner

Diáne Hershock

C. Blajman

Abstract

BACKGROUND: A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction chemotherapy with docetaxel plus cisplatin and fluorouracil (TPF) with cisplatin and fluorouracil (PF), followed by chemoradiotherapy. METHODS: We randomly assigned 501 patients...

Subject

Medicine

Docetaxel

Carboplatin

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