Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial

Gondi, Vinai; L. Pugh, Stephanie; A. Tomé, Wolfgang; Caine, Chip; Corn, B.; A. Kanner, Andrew; A. Rowley, Howard; Kundapur, Vijayananda; S. DeNittis, Albert; Greenspoon, Jeffrey; Konski, André; Bauman, Glenn; Shah, Sunjay; Shi, Wenyin; M Wendland, Merideth; A. Kachnic, Lisa; P. Mehta, Minesh

doi:10.1200/jco.2014.57.2909

Public

Preservation of Memory With Conformal Avoidance of the Hippocampal Neural Stem-Cell Compartment During Whole-Brain Radiotherapy for Brain Metastases (RTOG 0933): A Phase II Multi-Institutional Trial

Published in Journal of Clinical Oncology • Oct 28, 2014

Authors:

Vinai Gondi

Stephanie L. Pugh

Wolfgang A. Tomé

Abstract

PURPOSE: Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid conformally the hippocampal neural stem-cell compartment during WBRT (HA-WBRT). RTOG 0933 was a single-arm phase II study of HA...

Subject

Medicine

Hippocampal formation

Compartment (ship)

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