Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

Zhou, Ming; Zhao, Yuhua; Ding, Yan; Liu, Hao; Liu, Zixing; Fodstad, Øystein; I. Riker, Adam; Kamarajugadda, Sushama; Lu, Jianrong; B. Owen, Laurie; P. LeDoux, Susan; Tan, Ming

doi:10.1186/1476-4598-9-33

Public

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

Published in Molecular Cancer • Feb 9, 2010

Authors:

Ming Zhou

Yuhua Zhao

Yan Ding

Abstract

BACKGROUND: Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive clinical responses initially, the majority of patients eventually develop resistance to Taxol. Lactate dehydrogenase-A (LDH-A) is one of the predominant isoform...

Subject

Cancer cell

Lactate dehydrogenase

Biology

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