Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway

He, Sudan; Liang, Yuqiong; Shao, Feng; Wang, Xiaodong

doi:10.1073/pnas.1116302108

Public

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway

Published in Proceedings of the National Academy of Sciences • Nov 28, 2011

Authors:

Sudan He

Yuqiong Liang

Feng Shao

Abstract

We report here that mouse macrophages undergo receptor-interacting kinase-3 (RIP3)-dependent but TNF-α-independent necrosis when Toll-like receptors (TLR) 3 and 4 are activated by poly(I:C) and LPS, respectively. An adaptor protein, Toll/IL-1 receptor domain-containing adapter inducing IFN-β (TRIF/T...

Subject

Receptor

Cell biology

Toll-like receptor

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