Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.

S, He; Y, Liang; F, Shao; X, Wang

doi:10.1073/pnas.1116302108

Public

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway.

Shared by NobleBlocks on Nov 28, 2011 • 12:00 AM UTC

Authors:

He S

Liang Y

Shao F

Abstract

We report here that mouse macrophages undergo receptor-interacting kinase-3 (RIP3)-dependent but TNF-α-independent necrosis when Toll-like receptors (TLR) 3 and 4 are activated by poly(I:C) and LPS, respectively. An adaptor protein, Toll/IL-1 receptor domain-containing adapter inducing IFN-β (TRIF/T...

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